چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Opioid induced neuroinflammation is shown to be implicated in opioid analgesic tolerance development. In the present study the effect of pioglitazone on morphine-induced tolerance and neuroinflammation in the cerebral cortex of the rat was investigated. Materials and methods: Various groups of rats received morphine (10 mg/kg; ip) and vehicle (po), or morphine (10 mg/kg) and pioglitazone (20 or 40 mg/kg; po) once a day for 17 days. In order to determine the possible involvement of PPAR-g in the pioglitazone effect, one group of rats received PPAR-g antagonist, GW-9662 (2 mg/kg; sc), and pioglitazone (40 mg/kg) and morphine once daily for 17 days. Nociception was assessed using a tail flick apparatus and the percentage of the maximal possible effect was calculated as well. On 18th day, 2 h after the last morphine injection, the cerebral cortex of the animals were harvested and the tissue levels of tumour necrosis factor alpha, interleukin-1beta, interleukin-6, interleukin-10 and nuclear factor-kappa B activity were determined. Results: Co-administration of pioglitazone (40 mg/kg) with morphine not only attenuated morphineinduced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumour necrosis factor alpha, interleukin-1beta, interleukin-6) and nuclear factor-kappa B activity in the rat cerebral cortex. Moreover, GW-9662 (2 mg/kg) administration 30 min before pioglitazone, antagonized the above mentioned pioglitazone-induced effects. Conclusion: It is concluded that oral administration of pioglitazone attenuates morphine-induced tolerance. This effect of pioglitazonemay be, at least in part, due to its anti-inflammatory property which suppressed the cortical pro-inflammatory cytokine and inhibited of nuclear factor-kappa B activity. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد چرخ پور | دوم |
| مهران مسگری عباسی | چهارم |
| هادی همیشه کار | پنجم |
| صنم آرامی | هفتم |
| کامبیز حسن زاده | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Pioglitazone prevents morphine antinociceptive.pdf | 1398/03/05 | 278082 | دانلود |
