چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Long-term exposure to opiates such is morphine induces dependence. Purpose: The purpose of the present study was to investigate the eff ects of the acute administration of pioglitazone, a selective agonist of peroxisome proliferator activated receptors gamma (PPAR-γ), on the morphine withdrawal syndrome in the rat. Methods: Male Wistar rats (200–250 g) were selected randomly and divided into 8 groups including 2 non-dependent groups and 6 morphine- dependent groups which were received additive doses of morphine subcutaneously at an interval of 12 h for 9 continuous days. On the ninth day, only the morning dose of morphine was injected and 2 h later, morphine withdrawal was precipitated by naloxone and then ten distinct withdrawal behaviors were recorded for 45 min. Pioglitazone (5, 10, 20 and 40 mg/kg) was gavaged 2 h before naloxone injection. It is worth noting that 1 h before the pioglitazone (40 mg/kg) gavage, GW-9662 (2 mg/kg), a selective PPAR-γ antagonist, was administrated in order to evaluate the possible role of the PPAR-γ. Result and Discussion: The results of this study showed that administration of pioglitazone (40 mg/kg) decreased all withdrawal signs and the statistical analysis indicated that pioglitazone could attenuate the total withdrawal scores signifi cantly. Administration of GW-9662 had no signifi cant eff ect on pioglitazone attenuation eff ect on morphine withdrawal symptoms. Conclusion: Taking together, it was concluded that acute oral administration of pioglitazone prevented naloxone-precipitated withdrawal symptoms and GW-9662 could not revert its eff ect on morphine withdrawal syndrome. It seems that pioglitazone suppresses morphine withdrawal syndrome through PPAR-γ independent mechanisms. |
| نویسنده | نفر چندم مقاله |
|---|---|
| نسرین مالکی دیزجی | سوم |
| کامبیز حسن زاده | چهارم |
| محمد چرخ پور | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Acute Administration of Pioglitazone.pdf | 1398/03/05 | 390166 | دانلود |
