چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Betanin is a bioactive compound with a high antioxidant activity and therapeutic potential. However, incomplete oral absorption and low stability of betanin limit its application. To surmount these limitations, betanin was encapsulated with nanoliposomes, nanoparticles exhibiting suitable physicochemical properties. Additionally, betanin-loaded nanoliposomes revealed a relatively good sustained release profile in the simulated gastric and intestinal fluids. In vitro digestion stability of betanin and its antioxidant activity were significantly improved by liposomal encapsulation. These nanocarriers were assessed in vivo for their therapeutic potency in streptozotocin induced rats. The results showed that the administration of betanin-loaded nanoliposomes was significantly more effective than free betanin in positively regulate hyperglycemia, hyperlipidemia and oxidative stress. Moreover, the histopathological analysis showed that the tissue damage in kidney, liver and pancreas was reduced in the betanin-loaded nanoliposomes treated diabetic rats. In conclusion nanoliposomes are suitable nanocarriers for improving the stability and therapeutic potential of betanin. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ساجد امجدی | اول |
| مهران مسگری عباسی | دوم |
| بهروز شکوهی گوگانی | سوم |
| مرجان قربانی | چهارم |
| حامد همیشه کار | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2019-Amjadi-Betanin-J Functional Foods.pdf | 1398/03/04 | 3118171 | دانلود |
