چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. Objective. This study was conducted to investigate the effects of CoQ10 and/or vitamin E on cardiometabolic outcomes in patients with PCOS. Methods. This randomized clinical trial was carried out among 86 women with PCOS. Patients were assigned to take CoQ10, vitamin E, CoQ10 plus vitamin E or placebo for 8 weeks. Fasting blood samples were obtained at the beginning and end of the study. Results. A significant decrease in serum triglycerides (TG) ( p ! 0.001) was found following the administration of CoQ10 and/or vitamin E supplements compared with the placebo group. Supplementation with CoQ10 and vitamin E failed to affect total cholesterol levels. However, co-administration of CoQ10 and vitamin E resulted in a significant decrease in serum total cholesterol levels (9.92 [15.11, 4.74]). Additionally, only the combination of supplements was able to significantly reduce low-density lipoproteincholesterol (LDL-C) (‒9.63 [‒15.34, ‒3.92]), increase high-density lipoprotein-cholesterol (HDL-C) (2.33 [0.51, 4.16), reduce atherogenic coefficient (AC) (‒0.29 [‒0.43, ‒0.16], p 5 0.03) and decrease visceral adiposity index (VAI) values. Co-Q10 and vitamin E (alone or in combination) had significant effects on non-HDL-C ( p 5 0.004), atherogenic Index of Plasma (AIP) ( p 5 !0.001) and lipid accumulation product (LAP) ( p ! 0.001) and SBP ( p 5 0.005). However, the reduction in DBP was statistically significant only for patients who received combined supplementations ( p 5 0.04). Conclusions. In conclusion, CoQ10, vitamin E (alone or in combination) had beneficial effects on cardiometabolic outcomes among women with PCOS. 2019 IMSS. Published by Elsevier Inc. |
| نویسنده | نفر چندم مقاله |
|---|---|
| عظیمه ایزدی | اول |
| شبنم شیرازی زوارق | دوم |
| شیوا تقی زاده اصل | سوم |
| بهرام پورقاسم گرگری | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Independent and Additive Effects of Coenzyme Q10 and Vitamin E on1-s2.0-S0188440918308543-main.pdf | 1398/02/31 | 250707 | دانلود |
