چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Objectives: Anti-inflammatory therapeutic approaches are considered for the management of type 2 diabetes and for the prevention of its complications. There is limited evidence regarding the effects of prebiotics on inflammation, especially in patients with type 2 diabetes. This trial aims to examine the effects of oligofructose-enriched inulin on glycemic status, inflammation markers, and metabolic endotoxemia in female patients. Methods: Over a period of 8 wk, 52 women with body mass indices of >25 kg/m2 but <35 kg/m2 with type 2 diabetes were randomly assigned to either an intervention group, in which participants were given oligofructose-enriched inulin (n ¼ 27, consuming 10 g/d of oligofructose-enriched inulin), or to a control group, in which participants were given maltodextrin (n ¼ 25, consuming 10 g/d of maltodextrin). Fasting plasma glucose, glycosylated hemoglobin, high-sensitivity Creactive protein, interleukin-6, tumor necrosis factor-a, interferon-g, interleukin-10, and plasma lipopolysaccharide were measured before and after the intervention. Data were analyzed with the use of SPSS software version 13. Paired and unpaired Student t tests and analysis of covariance were used to compare quantitative variables. Results: Oligofructose-enriched inulin caused a significant decrease in the levels of fasting plasma glucose (19.2 mg/dL; 9.50%), glycosylated hemoglobin (1.0%; 8.40%), interleukin-6 (1.3 pg/mL; 8.15%), tumor necrosis factor-a (3.0 pg/mL; 19.80%) and plasma lipopolysaccharide (6.0 EU/mL; 21.95%) as compared with maltodextrin (P < 0.05). Decreases in levels of interferon-g (0.3 pg/mL; 16.50%) and high-sensitivity C-reactive protein (3.9 ng/mL; 31.70%) and an increase in the level of interleukin-10 (0.4 pg/mL, 11.50%) were not significant in the oligofructose-enriched inulin group as compared with the maltodextrin group. Conclusions: In women with type 2 diabetes and suboptimal daily dietary fiber intake, oligofructoseenriched inulin may help to modulate some inflammatory markers. |
| نویسنده | نفر چندم مقاله |
|---|---|
| پروین دهقان | اول |
| بهرام پورقاسم گرگری | دوم |
| محمد اصغری جعفرآبادی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| nutrition, Oligofructose-enriched inulin improves some inflammatory.pdf | 1398/02/30 | 407724 | دانلود |
