| Various tissues and cell types are the targets of vitamin D. However, the major targets of vitamin D in the immune
system are monocytes/macrophages, dendritic cells (DCs), as well as B and T cells. Vitamin D plays an
important role in the immune system modulation via regulating the expression of genes that generate pro-inflammatory
mediators and inhibiting the proliferation of pro-inflammatory cells, both of which have been implicated
in the pathophysiology of the inflammatory diseases. Recent studies have revealed the important relations
between vitamin D and Behçet’s disease (BD). Vitamin D function and its deficiency have been linked to a wide
range of metabolic disorders including malignant, cardiovascular, infectious, neuromuscular, and autoimmune
diseases. Here, we provide a brief analysis of the recent literature regarding immune-regulatory effects as well
as clinical evidence of vitamin D influence on the molecular level in BD. |