چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Rheumatoid arthritis (RA) is an infl ammatory disorder in which the disease severity might be decreased by anti-infl ammatory agents. There are several lines of evidence which support anti-infl ammatory effects of vitamin K. The aim of this study was to examine whether vitamin K is a useful strategy for reducing infl ammation in RA subjects. Materials and methods: In this double-blind placebo controlled trial, 58 patients with defi nitive RA were randomly allocated into two groups to receive vitamin K1 as phylloquinone [10 mg/day] or placebo pills for 8 weeks. Clinical status using disease activity score-28 (DAS-28) and serum concentrations of some infl ammatory markers (IL-6, hs-CRP,TNFα) were assessed at baseline and at the end of intervention. Results: There were no signifi cant differences between the two groups regarding any of the baseline characteristics. In the vitamin K1 group, a 27 % decrease in serum levels of IL-6 (P = 0.006) and a 13 % decrease in DAS- 28 (P = 0.041) were observed. However, after adjusting for relevant confounders, i. e.; duration of RA, intake of folic acid supplements, energy intake, weight and baseline values of each variable, by comparing the two groups, we found no signifi cant reduction in these markers. Conclusion: Vitamin K1 supplementation at 10 mg/day for 8 weeks had no signifi cant effects on blood biomarkers of infl ammation and disease severity of patients with rheumatoid arthritis compared with the placebo group. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ندا قمرزاد شیشوان | اول |
| بهرام پورقاسم گرگری | دوم |
| محمد اصغری جعفرآبادی | سوم |
| سوسن کلاهی | چهارم |
| سپیده حقی فر | پنجم |
| سهیلا نوروزی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Vitamin K1 Supplementation Did Not Alter Inflammatory Markers and Clinical Status in Patients with Rheumatoid Arthritis.pdf | 1398/04/20 | 973356 | دانلود |
| 2018 IMPACT FACTORS - Copy.pdf | 1398/04/20 | 49352 | دانلود |
| INT J VIt NUT RES indexes from CLARIVATE.pdf | 1398/04/20 | 330430 | دانلود |
| 1) Effects of Vitamin K on Matrix Metalloproteinase-3 and Rheumatoid Factor in Women with.pdf | 1398/04/22 | 153908 | دانلود |
| 2) Effects of phylloquinone supplementation on lipid profile in women.pdf | 1398/04/22 | 477250 | دانلود |
| 3) The Association between Anthropometric Indices and Disease Severity in Women.pdf | 1398/04/22 | 570496 | دانلود |
