| Background. Transferrin is a negative acute phase protein, which decreases during inflammation and infection. The aim of
the present investigation was to evaluate changes in the transferrin serum levels subsequent to non-surgical treatment of
chronic periodontal disease.
Methods. Twenty patients with chronic periodontitis and 20 systemically healthy subjects without periodontal disease, who
had referred to Tabriz Faculty of Dentistry, were selected. Transferrin serum levels and clinical periodontal parameters
(pocket depth, clinical attachment level, gingival index, bleeding index and plaque index) were measured at baseline and 3
months after non-surgical periodontal treatment. Data were analyzed with descriptive statistical methods (means ± standard
deviations). Independent samples t-test was used to compare transferrin serum levels and clinical variables between the test
and control groups. Paired samples t-test was used in the test group for comparisons before and after treatment. Statistical
significance was set at P < 0.05.
Results. The mean transferrin serum level in patients with chronic periodontitis (213.1 ± 9.2 mg/dL) was significantly less
than that in periodontally healthy subjects (307.8 ± 11.7 mg/dL). Three months after periodontal treatment, the transferrin
serum level increased significantly (298.3 ± 7.6 mg/dL) and approached the levels in periodontally healthy subjects (P <
0.05).
Conclusion. The decrease and increase in transferrin serum levels with periodontal disease and periodontal treatment, respectively, indicated an inverse relationship between transferrin serum levels and chronic periodontitis. |