| Objectives: A wide range of compounds are utilized in dentistry such as dental composites, resins and implants. The
successful clinical use of dental materials rely on their physiochemical properties as well as biological and
toxicological reliability. Different local and systemic toxicities of dental materials have been reported. Placement of
these materials in oral cavity for a long time period might yield in unwanted reactions. An extensive variety of
materials is used in dentistry including filling materials, restorative materials, intracanal medicines, prosthetic
materials, different types of implants, liners and irrigants. The increasing rate in development of the novel materials
with applications in the dental field has led to an increased consciousness of the biological risks and tempting
restrictions of these materials. The biocompatibility of a biomaterial used for the replacement or filling of biological
tissue like teeth always had a high concern within the health care disciplines for patients. Materials and Methods:
Any material used in humans should be tested before clinical application. There are many tests evaluating
biocompatibility of these materials at the point of in vitro, in vivo and clinical investigations. Results: The current
review discusses the potential toxicity of dental material and screening of their biocompatibility. Clinical Relevance:
It is essential to use healthy and safe materials medical approaches. In dentistry, application of different material in
long-term oral usage demands low or non-toxic agents gains importance for both patients and the staff. Furthermore,
screening tests should evaluate any potential toxicity before clinical application. |