| خلاصه مقاله | Evaluation of Sensitivity of US and MRI as a Complementary Modality for Mammography in High-Risk Women
Background:
Breast cancer is one of the most common and high-mortality cancers in women, especially in developing countries. Planning a precise and appropriate screening method for women at high risk (with a history of breast cancer in the family and carrying BRCA1 and BRCA2 genes) is essential. Mammography alone does not have high sensitivity and satisfaction. Therefore, in reviewing women at high risk, a modality should be added to mammography as a supplement. The choice of ideal mediation for mammography between ultrasound and MRI for screening women at high risk is the goal of this study.
Materials and Methods:
authors found 26 articles from database of scholar.google.com, scopus.com, and SID by searching keywords of “ breast ultrasonography” , “Breast MRI”, “screening high-risk women”, “ Breast cancer”., 17 articles were chosen as references.
Results:
Mammography is the standard method for screening breast cancer and its involvement in reducing breast cancer mortality has been proven. However, its sensitivity to high risk women is not satisfactory. Statistical data on the increase in sensitivity of mammography with ultrasound as well as mammogram with MRI is very different and depends on the factors studied in each study, such as the age of the patients, the pathology of the cancer, size and density of the breast, the type of device. The sensitivity range in previous studies was 20-90% for mammography, 40-92% ultrasound, MRI for 97-79.5%, and for Mammography + Ultrasound, 49% -91% and 86% -86% MRI, respectively. However, in all studies, performance improvement in any modality was clear on mammography alone. Ultrasound, however, increases the sensitivity as a complement to mammography. But this increase is not comparable to MRI, and MRI's sensitivity to mammography is very high and suitable for women at high risk.
Conclusion:
It seems that the design of the MRI screening screen with mammograms is suitable for women at high risk. However, with regard to cost, availability, tolerability and ... ultrasound can also be used as a supplement to mammography. Although this increase in sensitivity is not satisfactory. |