چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| By integrating high-performance CT imaging and photothermal therapy (PTT) into one nanoprobe, an e®ective theranostic can be achieved for clinical cancer treatment. In this study, the graphene quantum dots (GQDs)-coated bismuth (Bi) nanoparticle (NP) as a theranostic nanoprobe is synthesized and its capabilities for computed tomography (CT) imaging and PTT are investigated. Such nanotheranostic exhibits good physiological dispersity with satisfactory blood compatibility and cytotoxicity. Most importantly, the GQDs-Bi NPs o®er strong and steady absorbance pro¯le in NIR region with excellent photostability, which can remarkably convert photo-to-thermal with the photothermal e±ciency of 30.0%. Thanks to the powerful PTT e®ect, co-delivery of GQDs-Bi NPs/NIR laser can e®ectively induce HeLa cells death in vitro. Cooperatively, NPs hold X-ray attenuation coe±cient for high-contrast CT imaging with the corresponding CT improvement e±cacy as high as 32.7HUmg1. The obtained results highlight the potential of GQDs-Bi NPs as a successful theranostic nanoagent for CT imaging and cancer photothermal therapy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سمیره بدری گیلان | اول |
| اصغر مصباحی | چهارم |
| ناهیده قره آغاجی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Graphene Quantum Dots-Coated Bismuth.pdf | 1398/10/11 | 1009897 | دانلود |
