| Objectives:IntheNorthernDimensionAntibioticResistanceStudy(NoDARS),Finland,Germany,Latvia,Poland,RussiaandSwedencollectedurinesamplesfromoutpatientwomen(aged18–65years)withsymptomsofuncomplicatedurinarytractinfection(UTI)toinvestigatethelevelsofantimicrobialresistance(AMR)amongEscherichiacoliisolates.Methods:Atotalof775E.coliisolatesfrom1280clinicalurinesampleswerecollectedfromOctober2015toJanuary2017.AntimicrobialsusceptibilitytestingwasperformedandtheresultswereinterpretedaccordingtoEuropeanCommitteeonAntimicrobialSusceptibilityTesting(EUCAST)criteria.Results:OverallAMRratestothecommonlyusedantibioticsnitrofurantoin,fosfomycinandmecillinam(exceptforGermanythatwasmissingaresultformecillinam)were1.2%,1.3%and4.1%,respectively.Thehighestoverallresistanceratesweredeterminedforampicillin(39.6%),trimethoprim(23.8%),trimethoprim/sulfamethoxazole(22.4%),amoxicillin/clavulanicacid(16.7%)andciprofloxacin(15.1%),varyingsignificantlybetweencountries.Therateofextended-spectrumβ-lactamase(ESBL)productionwas8.7%.Noneoftheisolatesshowedresistancetomeropenem.Conclusions:Inmostcases,lowAMRratesweredetectedagainstthefirst-lineantibioticsrecommendedinnationalUTItreatmentguidelines,givingsupporttotheirfutureuse.TheseresultsalsosupporttheEuropeanAssociationofUrologyguidelinesstatingthatnitrofurantoin,fosfomycinandmecillinamareviabletreatmentoptionsforuncomplicatedUTI |