| Introduction: Several factors including fat free mass and fat mass can affect Basal Metabolic
Rate (BMR) as the largest component of daily energy demand. The aim of the current crosssectional
study was to compare BMR in women with secondary hyperparathyroidism and healthy
women and to evaluate its relationship with serum Parathyroid Hormone (PTH), fat free mass and
fat mass in these subjects. Materials and Methods: Sixty-eight women, 34 with secondary by
hyperparathyroidism and 34 healthy controls, aged between 17-50 years, participated in the current
study. Serum PTH, 25 hydroxy vitamin D and alkaline phosphatase were measured by the Enzyme
linked immunoassay technique (ELISA), Chemiluminescence Immunoassays (CLIA) and enzymatic
methods respectively. Serum calcium, phosphorous and magnesium were measured
calorimetrically. BMR, fat mass and fat free mass were analyzed by the Bioelectrical Impedance
Analyzer (BIA). Results: Mean BMR and fat free mass of women with secondary
hyperparathyroidism, was significantly lower than those of healthy ones (P<0.02). Serum PTH
concentration in women with secondary hyperparathyroidism was significantly higher and serum
phosphorous, significantly lower than healthy women (P<0.05). There was a significant negative
relationship between BMR and serum PTH in all participants. Fat mass and fat free mass were also
significantly correlated with BMR in both groups (P<0.05). Conclusion: According to our results,
there is a negative relationship between BMR and serum PTH in all study participants. Further
studies with interventional designs for inference of the causality of associations are warranted. |