چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| زهره صناعت | اول |
| رویا دولت خواه | دوم |
| علیرضا نیکانفر | سوم |
| یوسف روستا | چهارم |
| اشرف فخرجو | پنجم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Clinicopathological analysis of CD44 expression in HER2 positive invasive breast cancer Z. Sanaat*, R. Dolatkhah, Y. Roosta, A.R. Nikhanfar, A. Fakhrjou. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran Goals: The leading cause of cancer death in women is the breast carcinoma (BC), which is one of the most common malignancies around the world. Over expression of Human Epidermal Growth factor 2 (HER2), activates the cellular signaling growth factor in cells and this lead to oncogenic driver of breast cancer. Patients with HER2 positive faced with aggressive clinical behaviors and poor clinical outcome. CD44, as a trans-membrane glycoprotein molecule, involve in many cellular processes. Correlation between CD44 expression and BC cell proliferation, infiltration, angiogenesis, metastasis, and prognosis has also been reported. In this research study we evaluate correlation between CD44 expression and clinicpathologic significance in primary HER2-positive breast cancers. Methods: We studied specimens from 100 patients with HER2- positive invasive breast cancer. Immunohistochemical staining for CD44 was performed in all the specimens. We assessed any correlation between CD44 expression and clinicopathologic significance in HER2-positive breast cancer treated with trastuzumab. Results: Expression of CD44 was detected in 76% of patients. CD44 expression was significantly associated with tumor size (p = 0.01), lymph node (p = 0.01) and stage (p = 0.08). Also, CD44 expression was significantly associated with lymphatic (p = 0.006), vascular (p = 0.03) and neural (p = 0.03) invasions. CD44 expression was positively correlated with tumor size (r = 0.255, p = 0.01), lymph node 16th St.Gallen International Breast Cancer Conference / The Breast 44S1 (2019) S15–S78 S25(r = 0.261, p = 0.00) stage(r = 0.226, p = 0.02), lymphatic (r = 0.272, p = 0.01), vascular (r = 0.208, p = 0.04) and neural (r = 0.211, p = 0.03) invasion. Conclusions: The results from this study suggest that CD44 is clinically significant marker, which is associated with many Clinicopathological factors in breast cancers. Conflict of Interest: No significant relationships |
| کلمات کلیدی |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.pdf | 1398/02/02 | 65958 | دانلود |
| sgbcc2015.pdf | 1398/02/02 | 30832 | دانلود |
