چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Lithium is an effective and useful treatment for bipolar disorder and some central nervous system diseases. It has a narrow therapeutic index which results to acute and/or chronic intoxication. Lithium toxicity is as a result of prescribing error, reduced kidney elimination, drug-drug interactions or intentional overdose. Nephrotoxicity is one of clinical findings of chronic, acute and acute-on-chronic toxicity. Lithium was associated with increased risk of nephrogenic diabetes insipidus, kidney microcysts, tubulointerstitial disease for example tubular atrophy and chronic focal interstitial fibrosis and end-stage renal disease (ESRD). Several mechanisms such as blocks of sodium transportation through the amiloride-sensitive epithelial sodium channel and hyperparathyroidism were descriptive for the lithium nephropathy. Physicians should consider balance of risks before lithium therapy and monitor patients initial and during treatment according to clinical practice guidelines. Supportive care, withdrawal of lithium, gastrointestinal decontamination, increases renal perfusion, glomerular filtration rate, extracorporeal might be considered to lithium treatments. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد رضا اردلان | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 38.pdf | 1398/01/31 | 151388 | دانلود |
