چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| In the present study, a novel polymeric nanoparticle-based drug delivery system was developed to enhance the dissolution rate of poorly water-soluble drug pioglitazone hydrochloride (PGH) using hydrophilic Eudragit® RS100 (Eudr) as a carrier. The new nanoformulations were prepared in different drug : polymer ratios (1 : 5 and 1 : 10) at total solution concentrations of (5–20% w/v) employing electrospraying as onestep, self-dispersing, and productive method. The physicochemical attributes of the electrosprayed samples (ESs) were evaluated conducting scanning electron microscopy (FE-SEM), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transform infrared spectroscopy (FTIR) as well as in vitro dissolution studies. FE-SEM results indicated that the size and morphology of the ESs were influenced by the drug: polymer ratios and solution concentrations, where a rise in the polymer ratio led to the particle size augmentation while the solution concentration enhancement yielded in the fiber establishment. The DSC and XRPD analysis revealed amorphization of the drug where, the FTIR evaluation verified absence of any chemical interactions between the drug-polymer within the electrospraying procedure. In vitro release studies of the ESs exhibited biphasic release pattern with higher release rates compared to the pure drug. Our finding demonstrated that the electrospraying as a cost-benefit technique could be effectively employed to improve the physicochemical features of PGH. |
| نویسنده | نفر چندم مقاله |
|---|---|
| خسرو ادیب کیا | اول |
| محمد برزگر جلالی | دوم |
| کریم اصولی بستان آباد | چهارم |
| شهرام امامی | ششم |
| سولماز ذخیره | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Formulation of Pioglitazone Eudragit RS100 Nanobeads.pdf | 1398/01/28 | 1778054 | دانلود |
