| Abstract
For many years, cancer therapy has appeared to be a challenging issue for
researchers and physicians. By the introduction of novel methods in
immunotherapy, the prospect of cancer therapy even more explained than
before. Cytokine‐induced killer (CIK) cell‐based immunotherapy demonstrated
to have potentiality in improving clinical outcomes and relieving major side
effects of standard treatment options. In addition, given the distinctive features
such as high safety, low toxicity effects on healthy cells, numerous clinical trials
conducted on CIK cells. Due to the shortcomings that observed in CIK cell
immunotherapy alone, arising a tendency to make modifications (combined
modality therapy or combination therapy) including the addition of various
types of cytokines, genetic engineering, combination with immune checkpoints,
and so on. In this review, we have tried to bring forth the latest immunotherapy
methods and their overview. We have discussed the combination therapies with
CIK cells and the conducted clinical trials. This helps the future studies to use
integrated therapies with CIK cells as a promising treatment of many types of
cancers. |