Relationship Between Vitamin D Level and Bechcet's Disease Activity: A Systematic Review and Meta-Analysis

Relationship Between Vitamin D Level and Bechcet's Disease Activity: A Systematic Review and Meta-Analysis


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نویسندگان: علیرضا خبازی اسکویی , زینب نیک نیاز , مرتضی قوجازاده , سکینه حاج ابراهیمی

کلمات کلیدی: Behçet’s Disease; disease activity; vitamin D

نشریه: 55233 , 21 , 1 , 2019

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نویسنده ثبت کننده مقاله زینب نیک نیاز
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه بیماری های گوارش و کبد
کد مقاله 66354
عنوان فارسی مقاله Relationship Between Vitamin D Level and Bechcet's Disease Activity: A Systematic Review and Meta-Analysis
عنوان لاتین مقاله Relationship Between Vitamin D Level and Bechcet's Disease Activity: A Systematic Review and Meta-Analysis
ناشر 4
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ خیر
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Systematic Review Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت

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AIM: In the present study, the evidence about the association between vitamin D deficiency and Behcet's disease activity was systematically reviewed and meta-analyzed. METHOD: We searched the English and Persian databases of Medline (Ovid), CINHAL, Scopus, Proquest, the Cochrane library and SID, IranDoc, Magiran, Iran Medex for articles published up until May 2018 with the keywords were related to serum vitamin D and active and inactive Behcet's disease in adults. Meta-analysis was done using the CMA software. RESULTS: A total of 138 titles were retrieved and reduced to 80 titles after deletion of duplicates and finally after close assessing of titles and abstracts eight eligible studies including a total of 939 participants were identified for systematic review and meta-analysis. According to the results of the meta-analysis, the pooled effect size of the differences in the serum level of vitamin D in patients with inactive Behçet's Disease and healthy controls was [OR:-0.05; 95% CI:-2.05, 1.94; p = 0.95]. The serum vitamin D level was significantly lower in active patients compared with healthy controls [OR:1.21; 95%CI: -0.12, 2.31; p = 0.03]. The pooled effect size of the differences in the serum level of vitamin D in active and inactive Behçet's Disease was [OR:-0.71; 95%CI: -1.41, -0.007; p = 0.04] Conclusion: There is an association between vitamin D deficiency and active Behçet's Disease. Future studies investigating the association of vitamin D deficiency and Behçet's Disease needs to involve following information: dietary intake of calcium and vitamin D, measuring of sun exposure, report of drug consumption and physical activity level.

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نویسنده نفر چندم مقاله
علیرضا خبازی اسکوییاول
زینب نیک نیازچهارم
مرتضی قوجازادهدوم
سکینه حاج ابراهیمیسوم

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