چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مسعود ناظمیه | دوم |
| اکبر شریفی | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | |
| خلاصه مقاله | Background: Airway hyper responsiveness (AHR) is a characteristic feature of asthma. Methacholine challenge test (MCT) with spirometry is standard test for evaluating AHR, but this test has some restrictions in the diagnosis of AHR. MCT with impulse oscillometry (IOS) is a novel effort-independent method that directly measures airway resistance. Objectives: To compare the sensitivity of IOS and spirometry indices in order to assess a short protocol for MCT, in patients with symptoms suggesting AHR. Methods: This study, evaluated 235 adult patients with AHR symptoms and normal baseline spirometry, in lung diseases clinics, in Imam Reza hospital, Tabriz, Iran, in 2017. MCT with IOS as well as spirometry were performed. The primary endpoint was the Methacholine dose that caused a 20% reduction in FEV1 compared to baseline, or 40% increase in baseline respiratory resistance (Rrs5) measured by IOS. Results: These patients had a mean± standard deviation (STD) age of 34.79±1.30. The positive predictive value (PPV) of MCT with IOS, to detect a 20% reduction in FEV1, was 64.6% [95%CI 0.49-0.77] while for spirometry it was 30.1% [95%CI 0.23-0.38]. The area under the ROC curve was highest amount in the first stage performed using the IOS method, which was equal to 0.65 with p=0.01. Conclusion: The results showed the optimal sensitivity and negative predictive values of short protocol for MCT by IOS were higher than spirometry. During the challenge, the values of respiratory resistance at 5 Hz response preceded the FEV1 response. Therefore, IOS might be a reasonable screening test for detecting AHR |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.png | 1397/12/09 | 45981 | دانلود |
| 2.png | 1397/12/09 | 32676 | دانلود |
