چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| آیدا مالک مهدوی | اول |
| سوسن کلاهی | دوم |
| رضا مهدوی | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and Aim: Considering the important role of collagenases in joint destruction and pathogenesis of osteoarthritis (OA), this study aimed to investigate the effect of Lcarnitine supplementation on serum collagenases in females with knee OA. Methods: In this clinical trial, 72 females with mild to moderate knee OA were randomly divided into two groups to receive 750 mg/day L-carnitine (n=36) or placebo (n=36) for 8 weeks. Serum levels of collagenases-1 and -3 were assessed before and after supplementation. Data were analyzed by Wilcoxon signed rank test, Mann-Whitney’s U test, and analysis of covariance. Results: Only 69 patients (33 in the L-carnitine group and 36 in the placebo group) completed the study. Serum levels of collagenase-1 decreased significantly in the L-carnitine group (median percentage of changes [25th and 75th percentiles], -19.10% [-46.05, 3.47], P<0.021), whereas it had no change significantly in the placebo group (15.20% [-17.83, 93.76], P=0.381) after the supplementation period. Serum levels of collagenase-3 (-7.28% [-46.31, 96.93], P=0.742) were not changed significantly in the L-carnitine group after the study. Moreover, no significant changes were observed in the serum levels of collagenase-3 (median percentage changes 12.90% [-38.06, 104.67], P=0.561) in the placebo group after the study. At the end of the study, the results of ANCOVA test showed statistically significant differences between the two groups only in serum collagenase-1 levels (P<0.006), adjusted for baseline values and covariates. Conclusion: Despite observed beneficial effects of L-carnitine supplementation in decreasing serum levels of collagenase- 1 in knee OA patients, further studies are needed to achieve concise conclusions. |
| کلمات کلیدی | L-carnitine, Collagenase, Knee osteoarthritis |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2.jpg | 1397/11/28 | 245019 | دانلود |
| 02.jpg | 1397/11/28 | 402535 | دانلود |
