چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| آیدا مالک مهدوی | اول |
| سوسن کلاهی | دوم |
| رضا مهدوی | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | L-carnitine, Clinical status, Knee osteoarthritis, Obesity, Women |
| خلاصه مقاله | Background and Aim: L-carnitine has been reported to be helpful in the treatment of osteoarthritis due to its prophylactic role in cartilage degradation. The aim of this study was to investigate the effect of L-carnitine supplementation on clinical status in postmenopausal females with knee osteoarthritis (OA). Methods: In this clinical trial, 50 obese women with mild to moderate knee OA were randomly divided into two groups to receive 750 mg/day L-carnitine (n=25) or placebo (n=25) for 8 weeks. Clinical symptoms were assessed using the WOMAC Osteoarthritis Index. Data were analyzed by paired t-test, independent t-test, and analysis of covariance. Results: Only 48 patients (23 in the L-carnitine group and 25 in the placebo group) completed the study. Compared with baseline values, significant reductions of 42% (46.61 to 27.10), 48% (10.86 to 5.61), 48% (3.00 to 1.56) and 39% (32.73 to 19.91) in WOMAC total score and pain, stiffness, and physical function sub-scores, respectively were observed in the females supplemented with L-carnitine (P<0.001). Furthermore, in the placebo group, significant reductions were only observed in WOMAC pain sub-score (9.85 to 8.11, P=0.023). The results of ANCOVA showed statistically significant differences between the two studied groups in WOMAC total score and sub-scores at the end of the study, adjusted for baseline values (P<0.05). Conclusion: Although further studies are needed to confirm positive effects of L-carnitine on clinical status in knee OA patients, it seems that L-carnitine may provide a new complementary approach for patients with osteoarthritis of the knee. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.jpg | 1397/11/28 | 248873 | دانلود |
| 01.jpg | 1397/11/28 | 299146 | دانلود |
