چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Introduction: Toll‐like receptors (TLRs) are innate immunity receptors, which have an important role in modulating inflammation in disease. Cerebrolysin is a biotechnologically prepared peptide that stimulates neurotrophic regulation in the central nervous system. The aim of the present study was to investigate the effect of experimenting cerebrolysin on TLR2 and TLR4 in alcoholic liver disease (ALD). Materials and Methods: TLR2 and TLR4 expressions were determined using real‐time polymerase chain reaction in rats, which have used alcohol and they were separated into five groups. Results: The results of the present study showed that in mild dose of cerebrolysin, the expression of TLR2 and TLR4 was decreased significantly than other groups. Also, the results of the western blot analysis proved the same. Conclusion: The present study demonstrated that the anti‐inflammatory effect of cerebrolysin can decrease the TLR2 and TLR4 expressions through downregulating nuclear factor‐κB pathway in the ALD disease. |
| نویسنده | نفر چندم مقاله |
|---|---|
| جواد محمودی | اول |
| عطا محمودپور | دوم |
| مهدی امیرنیا | سوم |
| توحید کاظمی | چهارم |
| پونه چوخاچی برادران | پنجم |
| شیرین شیخ نجفی | ششم |
| سعید صدیق اعتقاد | هفتم |
| فرشته فرج دخت | هشتم |
| سیامک صندوقچیان | یازدهم |
| مبینا بلال زاده | دهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 10.1002@jcp.28293 (1).pdf | 1397/11/27 | 489834 | دانلود |
