Prospect of mesenchymal stem cells in therapy of osteoporosis: A review
Prospect of mesenchymal stem cells in therapy of osteoporosis: A review
نویسندگان: لیلی عاقبتی , صنم دولتی , علی فتوحی ملکی , مجید احمدی , علی عاقبتی ملکی , محمد نوری , سید کاظم شکوری بیلانکوهی , مهدی یوسفی
کلمات کلیدی: mesenchymal stem cell, osteoporosis, stem cell therapy
نشریه: 19614 , 1 , 9 , 2018
| نویسنده ثبت کننده مقاله |
لیلی عاقبتی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات ایمونولوژی |
| کد مقاله |
65811 |
| عنوان فارسی مقاله |
Prospect of mesenchymal stem cells in therapy of osteoporosis: A review |
| عنوان لاتین مقاله |
Prospect of mesenchymal stem cells in therapy of osteoporosis: A review |
| ناشر |
8 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Review Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
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| Osteoporosis is a systemic skeletal disease associated with reduced bone strong point that
results in raised fracture risk, with decreased bone strength, leading to reduced bone
mineral density and poor bone quality. It is the most common in older females but some
men are also at high risk. Although considered as a predictable result of aging, it is can be
avoidable and treatable. The existing treatment of osteoporosis mainly contains
antiresorptive and anabolic agents. In spite of these improvements, concerns around
unusual side‐effects of antiresorptive drugs, and the lack of perfect confirmation in
maintenance of their long‐standing effectiveness is bring about many patients not receiving
these drugs. Over the years, the stem cell‐based therapy has attained substantial clinical
consideration because of its potential to treat numerous diseases. The stem cell therapy
has been recommended as a probable therapeutic approach for patients with osteoporosis.
Even though the concept of stem cell‐based therapy for osteoporosis has caught
substantial attention, no clinical trial has been published on humans. The cell studies based
on osteoporosis are primarily focused on osteoclastic activity and bone resorption
procedures. Earlier, it was on osteoblastogenesis and in recent times, on the differentiation
probable of mesenchymal stem cells. In this review, we have summarized the therapeutic
role of stem cell‐based strategy in osteoporosis |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| Prospect of mesenchymal stem cells .pdf | 1397/11/16 | 651164 | دانلود |
| movafeghat.jpg | 1397/11/16 | 78564 | دانلود |