چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| A series of substituted 3-chlorophenylpiperazinone derivatives were synthesised using L-778123 (an imidazole-containing FTase inhibitor) as a model by bioisosteric replacement of the imidazole ring. The final compounds were evaluated against two human cancer cell lines including A549 (lung cancer) and HT-29 (colon cancer) by MTT assay. The results showed that substitution of imidazole ring with 1-amidinourea, semicarbazide, and thiobiuret led to improvement of cytotoxic activity against both cell lines. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سودابه داوران | سوم |
| سیمین شریفی | دوم |
| حسین دانافر | چهارم |
| داود عسگری | پنجم |
| جاوید شهبازی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Synthesis and Cytotoxicity Evaluation of Some Novel 1-(3 Chlorophenyl) piperazin-2-one Derivatives Bearing Imidazole Bioisosteres..pdf | 1397/11/01 | 517586 | دانلود |
