چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مهدی احمدی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 65634 |
| عنوان فارسی مقاله | اثر سیاه دانه و تیموکینون روی سطح اندوتلین در خوکچه هندی حساس شده با اوالبومین |
| عنوان لاتین مقاله | Effect of Nigella sativa and thymoquinone on endothelin level in ovalbumin-sensitized guinea pigs |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | اولین کنگره بین المللی فیزیولوژی و فارماکولوژی و بیست و دومین کنگره فیزیولوژی و فارماکولوژی ایران |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | |
| شهر محل برگزاری کنگره/ همایش | کاشان |
| سال انتشار/ ارائه شمسی | 1394 |
| سال انتشار/ارائه میلادی | |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1396/06/16 الی 1396/06/20 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.research.kaums.ac.ir |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهدی احمدی | اول |
| رعنا کیهان منش | دوم |
| لاله پژمان | سوم |
| فریبا میرزائی باویل | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Nigella sativa; Thymoquinone; Asthma; Endothelin; Guinea pig |
| خلاصه مقاله | Effect of Nigella sativa and thymoquinone on endothelin level in ovalbumin-sensitized guinea pigs Introduction: Nigella sativa extract has been used for treating asthma in traditional Medicine, but its exact mechanism is not obvious. Previous studies showed that thymoquinone, the main constituent of Nigella sativa, has bronchodilatory effects. So this study was proposed for determining the effect of hydro-ethanolic extract and thymoquinone on endothelin 1 level in bronchoalveolar lavage (BAL) and pulmonary tissue of experimental asthmatic guinea pigs. Method: 60 guinea pigs of both sexes were randomly divided to control (group C), animal model of asthma (group S), sensitized groups drinking water containing 0.125 g/dl Nigella sativa extract (group S+LNS), and 0. 25g/dl Nigella sativa extract (groupS+HNS) and sensitized groups drinking water containing 20μMthymoquinone (group S+LTQ) and 40μMthymoquinone (group S+HTQ). Results: The mean value of endothelin in BAL and lung tissue of sensitized group was significantly higher than in group C (p<0.001 to p<0.05).The mean value of endothelin in BAL and lung tissue in all pre-treated groups were significantly lower than S group (p<0.05).There was not any significant difference between groups S+LNS and groupS+HNS and between group S+LTQ and group S+HTQ.The mean value of endothelin in BAL and lung tissue in group S+LNS were significant in comparison with S+LTQ(p<0/01) but there was no significant difference between S+HNS and S+HTQ groups. Conclusion: It confirmed Nigella sativa and thymoquine have a reducing effect on endothelin level in both BAL and lung tissue in sensitized guinea pigs. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| poster_presentation_program.pdf | 1397/10/24 | 522831 | دانلود |
| kashan.jpg | 1397/10/24 | 390592 | دانلود |
| Poster En.rar | 1397/10/24 | 5026488 | دانلود |
