چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| شاهین احمدیان | اول |
| سپیده ششپری | دوم |
| مهران مسگری عباسی | پنجم |
| محمد نوری | ششم |
| رضا رهبرقاضی | هفتم |
| مهدی مهدی پور | هشتم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and Aim: Due to natural physiological aging, women at age 50-52 years old, face menopause and its related obstacle including infertility. Early menopause occurs in about 1% of women under 40 and 0.1% under 30 years in general population. Several causes have been identified for early menopause such as iatrogenic causes (mostly because of oncology treatment), idiopathic, genetic and autoimmune diseases. Several therapies have been proposed in this regard, however, the effectiveness of them remains to be further illustrated. Methods: In this study, we examined the restorative effect of Platelet-rich plasma (PRP) as a natural blood product in the rat model of menopause. The animal models were made within 15 days, using a daily injection of the gonadotoxic agent, 4-Vinylcyclohexene Diepoxide. The control group received saline in the whole period of animal modeling. After confirmation of menopause by hormonal (E2 and FSH) assessment and histological studies, a group of rats was injected (intra-ovarian injection) by freshly prepared rat PRP in two concentrations of 1 and 4X (15 rat/ group). Other two groups were either received saline or did not get any injection. Two months were assigned for evaluation of the treatment, in which every two weeks, 3 rats from each group randomly were allocated for hormonal and histological assessment of ovarian tissue. Results: Results indicate that the groups of rats who have received PRP in both concentrations restored somehow their ovarian function. Histological studies revealed that PRP treatment improved the follicle numbers of treated rats compared to the non-treated ones. Hormonal assessment as well showed a refinement pattern as the level of FSH has declined and the level of E2 has elevated significantly in the treated compared to non-treated rats. Conclusion: Our results illustrate that PRP could be applied as an alternative therapeutic agent for treatment of patients who are at early stages of menopause or about to enter into this complication such as cancer patients who are undergoing through gonadotoxic chemotherapy and radiotherapy. Quite optimistic, but further experimentations should be performed to approve the safety and applicability of the technique in the human setup. |
| کلمات کلیدی | Menopause; Infertility; Platelet-Rich Plasma; Animal Model; Ovarian rejuvenation |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| DDDDD.png | 1397/10/08 | 209515 | دانلود |
| Image (6).jpg | 1397/10/08 | 618686 | دانلود |
