چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs produce an enhanced hazard of severe gastrointestinaladverseeffects,specificallyinelderlypatients. Objectives: The current study aimed at formulating mucoadhesive microparticles of mefenamic acid to improve the therapeutic efficacyandpatientcompliance Methods: The microparticles were prepared by ionic gelation method sodium carboxymethyl cellulose (Na CMC) polymer. In the current study, the buccoadhesive microspheres holding various polymer-to-drug ratios were prepared and characterized by the following properties: encapsulation efficiency, FTIR (Fourier transform infrared) flowability, particle size, degree of swelling and surfacepH,DSC(differentialscanningcalormetric),mucoadhesiveproperty,retentivetime,andreleaseof drug Results:Thebestpolymer-to-drugratiointhemicrosphereswas4:1(asF3).TheproductionyieldofF3 microparticlesshowedamean of 99.30%,withaparticlesizeof 1905.46µmandloadingefficiencyof 46.56%. TheDSCshowedthatthemefenamicacid-loadedmicroparticleschangedtoamorphousform.BasedontheFTIRresults,thedrugmaintaineditschemicalstabilityduringtheencapsulationprocess.ItwasfoundthatthepreparedF3 microparticleshadmorereleaseratethanthemicroparticlesofF1,F2,anduntreated mefenamicacidpowder(P< 0.05). Themicroparticlesexhibitedverygoodretentiontimeproperties.Theresultsof mucoadhesive strengthandsurfacepHof discsshowedbettercharacterizationof microparticlesinbuccaladministration. Conclusions: Theformulationswereappropriatecandidatestoimprovemicroparticlesfortheremedialpurposes. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم مقصودی | دوم |
| میترا اعلمی میلانی | سوم |
| سارا سلاطین | چهارم |
| میترا جلوه گری | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| jjnpp-12-04-65324 shirzad.pdf | 1397/09/26 | 2067847 | دانلود |
