چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Common variable immunodeficiency (CVID) is the most common symptomatic form of primary antibody deficiency [1,2]. The underlying causes of CVID are largely unknown; however, genetic mutations are responsible for the disease in approximately 10%-20% of patients [3]. Furthermore, there is accumulating evidence that at least a subgroup of patients with CVID has a complex rather than a monogenic inheritance pattern [3]. Based on published cases, lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency is one of the most common monogenic disorders found during analysis of mutations in CVID patients [3,4]. Several studies have reported that T-cell abnormalities may be involved in the pathogenesis of immune dysregulation in CVID and LRBA deficiency [4,5]. Regulatory T cell (Treg) abnormalities due to low expression of forkhead box P3 (FOXP3) and CTLA-4 defects have also been reported [6]. Although lower levels of CTLA-4 protein have been found in patients with CVID and LRBA deficiency and associated with clinical presentations [1,7], no studies have compared the expression of CTLA-4 transcripts in the CD4+ T cells of patients with LRBA deficiency and CVID patients with no definitive genetic diagnosis. |
| نویسنده | نفر چندم مقاله |
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| فرهاد جدیدی نیارق | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
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| CTLA-4 Expression in CD4+ T Cells From Patients With LRBA Deficiency and Common Variable Immunodeficiency With No Known Monogenic Disease..pdf | 1397/09/27 | 329884 | دانلود |
