چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Alzheimer disease (AD) is an age-related and irreversible neurological disorder. The low efficacy of current therapeutic strategies is not only related to poor drug potency but also to the presence of various obstacles in the delivery routes like blood-brain barrier (BBB) that limits the uptake of most drugs by brain. Rivastigmine hydrogen tartrate (RHT) is used in the mildly to moderate of AD therapy of patients. Objectives: The present study described the use of PLGA nanoparticles (NPs) as effective delivery vehicles to improve the therapeutic efficiency of RHT. Methods: RHT-loaded PLGA NPs were prepared using interfacial polymer deposition following solvent displacement method with different ratios of polymer: drug. The NPs were studied for entrapment efficiency, particle size, and surface morphology using SEM (scanning electron microscopy), XRD (X-ray diffraction), FTIR (Fourier transform infrared spectroscopy), and DSC (differential scanning calorimetry). In vitro drug release from NPs was also assessed by a modified dissolution method. Results: The entrapment efficiency of RHT in NPs was found to be between 27.71±6.86 and 45.70±11.06 and the average size was about 75.14 to 173 nm. The zeta potential was negative (-2.28 to-10.5 mV), as determined by dynamic light scattering (DLS). The drug released from NP formulations was between 69.98%-89% upon 24 h, which indicated improved sustained drug release characteristics. Conclusions: These results suggested the potential usefulness of PLGA NPs for the delivery of RHT in a sustained and controlled manner. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا سلاطین | اول |
| ژاله برار | دوم |
| محمد برزگر جلالی | سوم |
| خسرو ادیب کیا | چهارم |
| میترا جلوه گری | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| jjnpp-13-4-12873-compressed.pdf | 1397/09/17 | 354069 | دانلود |
