چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| طاهره قدیری | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | effect of progesterone on post-traumatic epileptogenesis Background: despite numerous anti-epileptic effects of progesterone, limited number of studies have evaluated the anti-epileptogenic potency of this steroid. Considering the predisposal effect of TBI on developing post traumatic epilepsy (PTE) and the major role of brain derived neurotrophic factor (BDNF) signaling on epileptogenesis, this study was designed to investigate the effect of progesterone on preventing post-traumatic epileptogenesis and finding the mechanism(s) involved in the effect. Methods and materials: Progesterone was given 30 min, 6 h and then daily for 14 days after mild focal brain injury. To evaluate seizure susceptibility, seizure behavior parameters (by Racine scale) were assessed for 1 hour following application of a sub-convulsive dose of pentylentetrazole (PTZ, 30mg/kg), on the 15thday 0f TBI induction. The effect of progesterone on production of proteins involved in neurogenesis pathways (BDNF-TrkB, pERK, pCREB) in the ipsilateral hippocampus were determined. Results: Progesterone at dose of 32 mg/kg significantly reduced the duration and incidence of seizures but prolonged latency time (up to 60 min) compared to control group. Administration of 16 mg/kg progesterone elevated production of BDNF, and downstream proteins parallel to high seizure score. However, 32mg/kg progesterone declined the amount of neurotrophic factor, implying anti-epileptogenic and protective effects of progesterone. Discussion: Based on our findings, administration of progesterone at dose of 32mg/kg, indicates anti-seizure activity at day 15 after brain injury. Post-traumatic anti-epileptogenesis property of high dose of progesterone may partly occur through regulation of neurogenesis. |
| کلمات کلیدی | progesterone, BDNF,post-traumatic seizure, traumatic brain injury, rat |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 0041882.pdf | 1397/09/11 | 490627 | دانلود |
| abstract fens.docx | 1397/09/11 | 14860 | دانلود |
