چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: The effect of nutrition and dietary supplements as environmental factors has been suggestedas possible factors affecting both disease risk and progression in on the course of multiple sclerosis withcomplex genetic-risk profiles. This study was aimed to assess regulation of surface-membrane enzymessuch as Delta-6-desaturase (FADS2), secretory Phospholipase A2(sPLA2) by hemp seed and evening prim-rose oils as well as Hot-natured dietary intervention in relapsing remitting multiple sclerosis (RRMS)patients.Methods and materials: In this double blind, randomized trial, 100 RRMS patients with Extended disabilitystatus score (EDSS)<6 were allocated into 3 groups: “Group A” who received co-supplemented hemp seedand evening primrose oils along with advised Hot nature diet; “Group B”, who received olive oil; “GroupC”, who received the co-supplemented oils. Clinically EDSS and functional score as well as biochemicalparameters [blood cells polyunsaturated fatty acid (PUFA), FADS2, sPLA2] were assessed at baseline andafter 6 months.Results: Mean follow-up was 180 ± 2.9SD days (N = 65, 23 M and 42 F aged 34.25 ± 8.07 years with diseaseduration 6.80 ± 4.33 years). There was no significant difference in studies parameters at baseline. After 6months, significant improvements in EDSS and functional score were found in the groups A and C whileEDSS and pyramidal score showed significant increase in group B. Alteration of biochemical parametersshowed improvement in groups A and C whereas there was worsening condition for group B after theintervention.Conclusion: The co-supplemented hemp seed and evening primrose oils with Hot nature diet can havebeneficial effects in improving clinical symptoms and signs in RRMS patients which were confirmed byregulation of surface-membrane enzymes. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سید رفیع عارف حسینی | دوم |
| مهرانگیز ابراهیمی ممقانی | سوم |
| بهزاد برادران | چهارم |
| الیار صادقی حکم آبادی | پنجم |
| محمدعلی تربتی | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.pdf | 1397/09/03 | 578667 | دانلود |
