| Objective
This study aimed to compare the prevalence of 25-hydroxy vitamin
D deficiency in cerebral palsied (CP) with healthy control children and
evaluate possible correlations between serum level of 25-hydroxy vitamin
D and severity of CP and motor function.
Materials & Methods
In this case-control study, serum levels of 25-hydroxy vitamin D were
evaluated in 65 children with CP and compared with 65 healthy children
referred to Tabriz Pediatric Hospital, Tabriz, northwestern Iran in 2015.
Blood samples were taken to measure levels of 25-hydroxy vitamin D,
calcium, phosphorus and alkaline phosphatase. Regarding 25-hydroxy
vitamin D levels, patients were classified as sufficient (≥30 ng/ml),
insufficient (20-30 ng/ml) and deficient (<20 ng/ml).
Results
Mean 25-hydroxy vitamin D levels were 28.03±24.2 ng/ml in patients and
30±1.94 ng/ml in control group. 25-hydroxy vitamin D deficiency was seen
in 44.6% of CP and 18.5% of healthy children. There was no significant
difference in 25-hydroxy vitamin D levels between boys and girls, CP types
and use of antiepileptics in case group. There was significant negative
correlation between age and 25-hydroxy vitamin D levels (P=0.007). The
correlation between 25-hydroxy vitamin D and Gross Motor Function
Classification System was not significant.
Conclusion
25-hydroxy vitamin D deficiency is common in children with CP in
comparison with healthy children. There was significant negative correlation
between age and 25-hydroxy vitamin D levels. Routine measurement of
25-hydroxy vitamin D levels and its proper treatment is recommended to
prevent its deficiency and subsequent consequences. |