| The original cohort: The AZAR Cohort is a cohort for the 15 study of common non-communicable disorders, with a focus on gene-environmental interaction in the context of rapid environmental and social transition. The pilot phase started in 2014 with enrolment of 949 participants, and continued with the recruitment phase in 2015 and 14 997 20 participants aged 35–70 years old. The new focus: The AZAR Cohort is located in north-west Iran (Azerbaijan province). Iranian Azeris are the largest minority in the country. With a Caucasian ethnic background, they are the world’s largest Azeri population who 25 are a Turkic ethnic group. The location of cohort is next to Lake Urmia which was the largest lake in the Middle East and the sixth largest saltwater lake in the world, but now has now shrunk to 10% of its former size. Who is left? The most recent data collection, in 2016, in30 cluded 14 557 participants, aged between 35 and 70 years. New Measures: Main categories of data collected are: demographics, socioeconomic status, lifestyle factors (including physical activity, substance use), occupational history (including occupational exposures), past medical history, 35 medicine use (past and present), family medical history, gynaecological and obstetric history (for women), oral and dental health, circadian rhythm, dietary habits (including food processing and cooking methods), psychiatric evaluations (affective symptoms, sleep pattern), and environmen40 tal factors (including mobile phone use, pesticide use, lodging). Dietary pattern is measured using a food frequency questionnaire (FFQ). The FFQ covers 130 food items, including bread and cereals, meat and dairy products, oils, sweets, legumes, vegetables, fruits, and condi45 ments, as well as cooking methods.
Key new findings and/or unique features: The rapidly changing ecological factors are the unique features of this cohort.
Reasons to be cautious: Issues of concern include emigra50tion of participants, diagnosis of a disease incident outside the study region, loss to follow-up, and logistic issues.
Collaboration and data access: To further support national and international collaborations, the AZAR Cohort group collaborates with international experts. It uses online com55munication tools via its website to disseminate the collected information from the AZAR Cohort, to increase awareness, and to attract international collaborators [http://azarcohort.com]. |