| Objective: To evaluate the effect of supplementary administration of Anaheal capsule in
reducing pain, swelling and trismus after surgical removal of impacted mandibular third
molars. Material and Methods: This single-blind controlled randomized clinical trial
was conducted on 36 patients referring to Tabriz University of Medical Sciences. Each
of the 36 patients had bilateral surgical removal of mandibular third molars in two
sessions, with at least a 4-week interval between sessions. In the same individual, one of
the sites randomly received a test medication whereas the other site was used as a
control. In the test subgroup (test medication side), the first dose of Anaheal capsule was
given as a 200-mg dose of bromelain immediately after surgery according to
manufacturer’s instructions and the subsequent doses were given at 6-hour intervals
after the first dose. The medication was administrated for 3 days. In the control
subgroup (control side), Anaheal was not administered. The severities of pain, swelling
and maximum mouth opening (MMO) were recorded one and three days
postoperatively. Paired t-test and t-test for independent samples were used. Statistical
significance was defined at p<0.05. Results: A total of 72 surgical extractions were
performed; 36 procedures served as control and 36 cases received Anaheal. Pain,
swelling and trismus of the patients were at the highest levels one day after surgery,
which decreased on day 3. However, independent t-test showed no significant
differences in pain, swelling and trismus after surgery between the study subgroups
(p>0.05). Conclusion: Supplementary administration of Anaheal (800 mg bromelain
daily) had no significant effect on decreasing pain, swelling and trismus at 1- and 3-day
intervals after surgical removal of mandibular third molars. |