چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract Purpose In this study, we systematically investigated and analyzed articles focusing on the prognostic value of E-cadherin (E-cad) in human head and neck squamous cell carcinoma (HNSCC). Methods Searching through the diferent databases, the studies examining the associations between E-cad and HNSCC prognosis were identifed. Outcomes such as disease-specifc survival and overall survival were considered acceptable. Hazard ratio (HR) with 95% confdence interval (CI) was used to demonstrate prognostic value. Results A total of 40 studies were systematically analyzed, and fnally, 1939 subjects were included in our meta-analysis. Our fndings showed that signifcant aberrant expression of E-cad was associated with poor survival. However, some studies showed increased expression of E-cad in metastatic lesions was associated with poor prognosis. Alteration in location of E-cad expression also showed signifcant association with cancer survival, i.e., increased cytoplasmic E-cad. We conducted a meta-analysis on the eligible articles using a random efect model because of moderate heterogeneity. Strong association between aberrant expression of E-cad and poor survival was demonstrated (pooled HR=2.28; 95% CI 1.78–2.91). Conclusions Aberrant expression of E-cad may be a promising prognostic signature for HNSCC, especially when it is used with other prognostic markers. |
| نویسنده | نفر چندم مقاله |
|---|---|
| جواد یزدانی | اول |
| محمدعلی قویمی | دوم |
| الهه جباری حق | سوم |
| فرزین احمدپورپورناکی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 4_5847931404700091516.pdf | 1397/09/13 | 1341998 | دانلود |
