| Hyperbaric oxygen therapy (HBOT) is a treatment procedure that involves breathing 100% O2 for a certain time
and under a certain pressure. HBOT is commonly administrated as a primary or alternative therapy for different
diseases such as infections. In this paper, we reviewed the general aspect of HBOT procedures, the mechanisms
of antimicrobial effects and the application in the treatment of infections. Parts of the antimicrobial effects of
HBOT are believed to result of reactive from the formation of reactive oxygen species (ROS). It is also said that
HBOT enhances the antimicrobial effects of the immune system and has an additive or synergistic effect with
certain antimicrobial agents. HBOT has been described as a useful procedure for different infections, particularly
in deep and chronic infections such as necrotizing fasciitis, osteomyelitis, chronic soft tissue infections, and
infective endocarditis. The anti-inflammation property of HBOT has demonstrated that it may play a signifcant
role in decreasing tissue damage and infection expansion. Patients treated by HBOT need carful pre-examination
and monitoring. If safety standards are strictly tracked, HBOT can be considered a suitable procedure with an apt
rate of complication. |