چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| ندا روشن روان | اول |
| علیرضا استاد رحیمی | دوم |
| نعیمه مصری علمداری | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Butyrate, Hs- CRP- Mir- 200c, Diabetes |
| خلاصه مقاله | Objective: The cross-talk between diabetes and cardiovascular disease (CVD) is complex. Diabetes considerably increases the risk of heart disease. MicroRNAs have been linked to different diseases such as diabetes and altered expression of them may use for early detection of asymptomatic CVD in diabetes. The aim of this study was to evaluate the effects of butyrate (as a postbiotics product) supplementation on the expression of miR-200c and miR-21 as early biomarkers of oxidative stress- induced CVD, in diabetic patients. Methods: Over a period of 6 wk, 46 patients with 27 < BMI < 35 kg/ m2 with type 2 diabetes were randomly assigned to either an intervention group, in which subjects were given sodium butyrate (n = 23, consuming 600 mg/d of NaBut), or to a control group, in which participants were given placebo (n = 23, consuming 600 mg/d of starch).We assessed the tumor necrosis factor-αmRNAexpression in the peripheral blood mononuclear cells, as well as the plasmatic level of the miR-200c and miR21. In addition, the fasting blood sugars, glycosylated hemoglobin, highsensitivity C- reactive protein were measured before and after the intervention. Data were analyzed with the use of SPSS software version 23. Results: The results showed that tumor necrosis factor-α mRNAexpression was decreased in intervention group as compared to placebo (fold change: 0.740 ± 0.228, vs.1.504 ± 0.088, p = 0.041). Furthermore, the expression of miR- 200c decreased in butyrate group (0.415 ± 0.059, p < 0.001) against its constant level in placebo group (p<0.05).Interestinglybutyratecausedasignificantdecreaseinthelevels of fasting blood sugar (8.5%) and high-sensitivity C-reactive protein (32.4%) as compared with placebo (P<0.05).There was also an intense positivecorrelationbetweenmiR-200cwithfastingbloodsugarandhighsensitivity C-reactive protein in intervention group (p < 0.05). Conclusions: There is strong evidence for main role of miR-200c in CVD. Our preliminary results showed that the circulating level of miR200cdecreasedsignificantlyfollowingbutyratesupplementation.Moreover, there is a positive correlation between circulating miR-200c and highsensitivity C-reactive protein as a cardiovascular risk marker in patients with diabetes. Nevertheless, miR-200c may illustrate a potential novel therapeutic target. However, further investigations are needed to make concise conclusions. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 13.pdf | 1397/08/23 | 112325 | دانلود |
| oral antalya.jpg | 1397/08/23 | 133376 | دانلود |
| antalya.jpg | 1397/08/24 | 192143 | دانلود |
