چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| پرینا اصغریان | دوم |
| سولماز اثناعشری | سوم |
| زهرا قلبی | اول |
| عباس دل آذر | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Abstract Introduction: The risk of drug resistance and the use of medicinal plants in malaria prevention and treatment have led to the search for new antimalarial compounds with natural origin. Artemisinin was one of the top list of these herbal medicinal products with an endoperoxide sesquiterpene lactone structure, which was derived from Artemisia annua and demonstrated potent anti-malarial effect. The objectives of this study is evaluation of the anti- malarial effect of different extracts of all parts of Ecballium elaterium and aerial parts of Artemisia marschalliana. Methods: dried powder plants was extracted (with n-hexane, dichloromethane (DCM) and methanol (MeOH)),and anti- malaria were investigated by Cell free 𝛽-Hematin formation method respectively. Results: The MeOH extracts of Artemisia marschalliana (IC50=0.0105±0.0094) and The MeOHextracts of root of Ecballium elaterium (IC50=0.0293±0.0374) compared to positive control (chloroquine (IC50=0.014±0.003)) show significant inhibition of heme biocrystallization. Conclusion: The MeOH extracts of Artemisia marschalliana and The MeOH extracts of root of Ecballium elaterium showed the significant potential antimalarial effects. |
| کلمات کلیدی | : Artemisia marschalliana. Ecballium elaterium. Antimalaria .IC50 inhibitory concentration |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| certificate congereye hamedan.jpg | 1397/08/29 | 577561 | دانلود |
| kholase maghalat.doc | 1397/08/29 | 3091456 | دانلود |
