چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Introduction: Cardiovascular diseases and acute myocardial infarction have been considered as the most common alternative in hospitalized patients in developed countries. The present study aimed to evaluate the protective effect of aerobic exercise training and resveratrol supplementation on the oxidative stress and apoptosis in the rats with acute myocardial infarction due to isoproterenol application. Methods: In this study, a total number of 50 male Wistar rats were randomly categorized into five groups (n=10): Healthy mice or Control group (C), Isoproterenol group (ISO) that received isoproterenol (150 mg/kg body weight), ISO+exercise group(ISO+Ex) that rats ran for eight weeks on treadmill, ISO+Resveratrol group(ISO+Res) that animals received 25 mg/kg/bw of resveratrol per day for eight weeks and ISO+Exercise+Resveratrol group(ISO+Ex+Res). Isoproterenol subcutaneously administrated at the end of procedure on two consecutive days. Twelve hours after the second isoproterenol injection, Electrocardiography pattern were recorded then all animals were sacrificed to samples collecting for glutathione peroxidase, malondialdehyde, and apoptosis estimation. Results: Pretreatment of rats with resveratrol, exercise, and their combination significantly increased the levels of glutathione peroxidase activity and decreased malondialdehyde and apoptosis markers in comparison with ISO alone-induced rats (P< 0.01). These changes in the ISO+Ex+Res group were more than those in ISO+Res and ISO+Ex groups. ECG patterns were close to the normal in resveratrol, exercise, and resveratrol+ exercise pretreated rats administered with ISO. Conclusion: Regular aerobic exercise and resveratrol strengthen antioxidant defense system and attenuate oxidative stress. It appears that pretreatment with a combination of these two interventions prevents the destruction of myocytes and development of apoptosis |
| نویسنده | نفر چندم مقاله |
|---|---|
| عباس ابراهیمی کلان | دوم |
| بهرام جمالی قراخانلو | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Resveratrol.pdf | 1397/08/20 | 353975 | دانلود |
