چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| In this study, a novel nano-composite based on poly‑taurine/beta‑cyclodextrin and graphene quantum dot used for the modification of gold electrode by simple electrodeposition approach. The prepared interface was applied for the sensing of doxorubicin hydrochloride (DOX) in human plasma samples without any pretreatment procedure. The synergistic influence of poly-taurine, beta-cyclodextrin, and graphene quantum dot not only remarkably enhances electroactivity, but also speeds up the electron shift between DOX and the electrode substrates. Cyclic voltammetry results indicated that the DOX is oxidized via two electrons and two protons process at the optimum pH = 4 using poly-taurine/beta-cyclodextrin and graphene quantum dots thin film modified gold electrode. More momentously electrostatic repulsion takes place between the prepared polymeric film and DOX resulting in the signal amplification on oxidation of this drug and lowering its overpotential and thereby sensitive and selective detection of DOX in real samples. The apparent electron transfer rate constant and transfer coefficients were determined by cyclic voltammetry. Using differential-pulse voltammetric (DPV) technique sensitive determination of DOX in human plasma samples was performed with wide dynamic range and good limit of detection. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد حسن زاده محله | دوم |
| ابوالقاسم جویبان | پنجم |
| پرستو محمد علیزاده | اول |
| جعفر سلیمانی | سوم |
| جلیل واعظ قراملکی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 166.pdf | 1397/08/19 | 630888 | دانلود |
