| In recent years, liquid phase microextraction (LPME) as a solventeminimized and microscale implementation
of sample pretreatment procedure of liquideliquid extraction has been introduced and obtained
great attention among the researchers due to its simplicity, low cost, rapidity, and efficiency.
Developments have led to different approaches of LPME such as headspace mode of liquid phase
microextraction (HS mode of LPME) which is used in the cases of volatile and semievolatile analytes. In
HS mode of LPME, the extractant is suspended in the headspace of analytes solution and has no contact
with the sample solution which leads to eliminate interferences problem. The present review discusses
HS mode of LPME with the focus on its historical developments, principles, configurations, inherent
limitations, and pros and cons. Herein, recent analytical applications of the method used in the isolation
and trace enrichment prior to analysis of various compounds are reviewed. The future direction of the
researches in this field and general trend toward the commercial applications are also considered. |