چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Oxidativestressinthepathogenesisof diabetesisof greatprominenceandthatCarnosineisanaturalantioxidant. Objectives: This studywasaimedto investigatetheeffectof Carnosine supplementationon differentoxidative stressbiomarkers inpatientswithtype2diabetesmellitus(T2DM). Methods: In this randomized, double-blind placebo-controlled clinical trial, 54 patients with T2DM were employed from Tabriz SheikhorraeespolyclinicandTabrizImamRezaHospital,endocrinecenter,andassignedintoeithertheinterventiongroup(n=27) to receive two capsules of Carnosine 500 mg each or the control group (n = 27) to take two capsules of crystalline microcellulose for12weeks. Serumlevelsof fastingbloodsugar(FBS),malondialdehyde(MDA),proteincarbonyl(PC)anderythrocytescontentof catalase(CAT),andsuperoxidedismutase(SOD)wereassessedbeforeandafterthesupplementation. Results: A total of 54 patients completed the study. Anthropometric indices and dietary intakes of micronutrients didn’t show a significant change in both studied groups. Improved CAT level and decreased serum levels of FBS, MDA, and PC occurred in the carnosine group compared to the placebo group after adjusting for baseline values and confounders (P < 0.05). Between-group differenceswerenotsignificantforothervariablesattheendof theresearch.Intheplacebogroup,noneof thestudiedbiomarkers werealteredsignificantly. Conclusions: Our findings divulge the beneficial effects of carnosine supplementation in improving the antioxidant status and attenuatingsomeof theoxidativestressbiomarkersinpatientswithT2DMmakingitausefuladjuncttherapy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ثریا خیروری | دوم |
| اسماعیل فرجی | سوم |
| محمد اصغری جعفرآبادی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ircmj-2018.pdf | 1397/08/14 | 757386 | دانلود |
