| Abstract
Introduction: The objectives of this study were to provide an estimate of the prevalence of metabolic syndrome
(MetS) and its components among women with PCOS; and calculate the odds ratio (OR) for MetS (using different
definitions of MetS) in women with PCOS, compared to healthy controls.
Methods: All of the relevant databases were used to search for appropriate articles that were published during
the period 2003-2016. We included observational studies (cross-sectional, comparative cross-sectional) among
women who met the inclusion criteria. The random-effect models were used to pool the prevalence of MetS and
its components among PCOS women. This model was also applied to the pooled OR assessing the association
between MetS and PCOS.
Results: The pooled prevalence of MetS among PCOS women was found to be 26.30% (95% CI: 23.68–28.93),
but varied from 7.10% (95% CI: 1.64-12.56) to 37.50% (95% CI: 28.84-46.16), depending upon the diagnostic
criteria used. Low high-density lipoprotein cholesterol (HDL) - 61.87% (95% CI: 53.31–70.43) and high waist
circumference (WC)- 52.23% (95% CI: 43.84–60.61) were the most common components of MetS in PCOS
women. Compared to healthy controls, the overall pooled (OR) of MetS in PCOS patients was 2.09 (95% CI:
1.67-2.60), but this ranged from 0.31 (95% CI: 0.13-0.74) to 4.69 (95% CI: 2.09-10.52), depending upon the
diagnostic criteria used.
Conclusion: Women with PCOS had a much higher prevalence of MetS than was found among the healthy
controls. Furthermore, as low HDL and high WC were the most common components of MetS in PCOS women,
these two components specifically need to be addressed in prevention strategies. |