Epidemiology and patterns of drug resistance among tuberculosis patients in Northwestern Iran

Epidemiology and patterns of drug resistance among tuberculosis patients in Northwestern Iran


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نویسندگان: لیلا صاحبی , خلیل انصارین , مهدیه سیدی , صفر فرج نیا , سید رضا مودب , جلیل راشدی

کلمات کلیدی: MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; PREVALENCE; TRENDS

نشریه: 14674 , 3 , 34 , 2016

اطلاعات کلی مقاله
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نویسنده ثبت کننده مقاله خلیل انصارین
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه مرکز تحقیقات سل و بیماری های ریوی
کد مقاله 64564
عنوان فارسی مقاله Epidemiology and patterns of drug resistance among tuberculosis patients in Northwestern Iran
عنوان لاتین مقاله Epidemiology and patterns of drug resistance among tuberculosis patients in Northwestern Iran
ناشر 7
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ خیر
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت

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Background: Multidrug-resistant tuberculosis (MDR-TB) has emerged as an important global health concern and is on the rise throughout the world. Objective: The aim of this study was to examine the epidemiology and pattern of TB drug resistance. Methods: In this cross-sectional study, 180 pulmonary TB patients from two Northwestern provinces of Iran were selected. The first and second line drug susceptibility testing was carried out using the 1% proportion method on the L phi wenstein-Jensen medium. Full demographic, environmental and clinical history was evaluated. Results: Prevalence of resistance to any TB drug was 13.8%. Eight (4.4%) patients had MDR-TB (2.4% in the province of East Azerbaijan and 9.3% in the province of Ardabil) and one patient had extensively drug-resistant TB. Patient resistance to both isoniazid and streptomycin was the most prevalent at a rate of 8.3%. Patients showed the least resistance to ethambutol (2.8%). There was a significant relationship between the previous history of TB drug treatment and TB drug resistance. Migrants from rural to urban areas were in high-risk groups for the occurrence of TB drug resistance. Conclusion: In our study, prevalence of MDR was less than the global average. It is essential to monitor the patients with previous history of TB treatment and migrants by rapid and accurate techniques in terms of drug-resistance odds.

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نویسنده نفر چندم مقاله
لیلا صاحبیاول
خلیل انصاریندوم
مهدیه سیدیسوم
صفر فرج نیاپنجم
سید رضا مودبششم
جلیل راشدیهفتم

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