چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The Wnt signaling pathway consists of various downstream target proteins that have substantial roles in mammalian cell proliferation, differentiation, and development. Its aberrant activity can lead to uncontrolled proliferation and tumorigenesis. The posttranslational connection of fatty acyl chains to Wnt proteins provides the unique capacity for regulation of Wnt activity. In spite of the past belief that Wnt molecules are subject to dual acylation, it has been shown that these proteins have only one acylation site and undergo monounsaturated fatty acylation. The Wnt monounsaturated fatty acyl chain is more than just a hydrophobic coating and appears to be critical for Wnt signaling, transport, and receptor activation. Here, we provide an overview of recent findings in Wnt monounsaturated fatty acylation and the mechanism by which this lipid moiety regulates Wnt activity from the site of production to its receptor interactions. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سید وحید حسینی | اول |
| محمد حسین گرانمایه | سوم |
| فاطمه محمدزاده | چهارم |
| سعید نظری سلطان احمد | پنجم |
| مسعود دارابی امین | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Journal of Cellular Physiology Volume issue 2018 [doi 10.1002_jcp.27570] Hosseini, Vahid; Dani, Christian; Geranmayeh, Mohammad Hossein; -- Wnt lipidation- Roles in trafficking, modulation, and func.pdf | 1397/08/13 | 1007455 | دانلود |
| 2645e66c-925c-4d0f-b46c-65302b3a30e1.jpg | 1397/08/20 | 35586 | دانلود |
