چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The topic of cancer stem cells is of significant importance due to its implications in our understanding of the tumor biology, as well as the development of novel cancer therapeutics. However, the question of whether targeting cancer stem cells can hamper the growth of tumors remains mainly unanswered due to the lack of specific agents for this purpose. In order to address this issue, we have developed the first mutated version of herpes simplex virus‐1 (HSV‐1) that is transcriptionally targeted against CD133+ cells. CD133 has been portrayed as one of the most important markers in cancer stem cells involved in the biology of a number of human cancers, including liver, brain, colon, skin, and pancreas. The virus developed in this work, Signal‐Smart 2 (SS2), showed specificity against CD133+ cells in three different models (hepatocellular carcinoma, colorectal cancer, and melanoma) resulting in a loss of viability and invasiveness of cancer cells. Additionally, the virus showed robust inhibitory activity against in vivo tumor growth in both preventive and therapeutic mouse models as well as orthotopic model highly relevant to potential clinical application of this virus. Therefore, we conclude that targeting CD133+ cancer stem cells has the potential to be pursued as a novel strategy against cancer. |
| نویسنده | نفر چندم مقاله |
|---|---|
| رویا دولت خواه | ششم |
| زهره صناعت | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Stem Cells.pdf | 1397/08/20 | 3027327 | دانلود |
