Application of chitosan as biocompatible polysaccharide in quantification of some benzodiazepines affecting sleep disorders: A new platform for preparation of bioactive scaffolds
Application of chitosan as biocompatible polysaccharide in quantification of some benzodiazepines affecting sleep disorders: A new platform for preparation of bioactive scaffolds
نویسندگان: محمد حسن زاده محله , ابوالقاسم جویبان , حمیده اشرفی
کلمات کلیدی: Bioactive polysaccharide, Nanomaterials, Bioanalysis, Benzodiazepine, Sleep disorders, Drug metabolism
نشریه: 15718 , 01 , 120 , 2018
| نویسنده ثبت کننده مقاله |
محمد حسن زاده محله |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات کاربردی دارویی |
| کد مقاله |
64374 |
| عنوان فارسی مقاله |
Application of chitosan as biocompatible polysaccharide in quantification of some benzodiazepines affecting sleep disorders: A new platform for preparation of bioactive scaffolds |
| عنوان لاتین مقاله |
Application of chitosan as biocompatible polysaccharide in quantification of some benzodiazepines affecting sleep disorders: A new platform for preparation of bioactive scaffolds |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
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| Herein, a reusable and time-saving strategy for the electrochemical polymerization of dopamine (EPD) in the presence of chitosan is reported. In this work, biocompatible polymer chitosan (CS) was electrodeposited on the surface of PDA modified glassy carbon electrode using layer-by-layer strategy. Owing to the abundant catechol and amine groups in the PDA layer, uniform gold nanoparticles (Au NPs) are deposited onto the POLY(DA-CS) and can effectively prevent the recombination of electron-hole pairs generated from photo-electrocatalysis and transfer the captured electrons to participate in the electrocatalytic reaction process. Compared with POLY(DA-CS), the as-prepared POLY(DA-CS)-AuNPs organic-inorganic hybrid exhibit electrochemical sensitivity for the detection of some benzodiazepines and display excellent durability. Furthermore, the mussel-inspired electropolymerization strategy and the fast EPD-Au nanoparticle decorating process presented herein can be readily extended to various biomedical and pharmaceutical analysis. It is the adaptation of the established POLY(DA-CS)-Au NPs organic-inorganic hybrid for a selective, robust, and generalizable sensing system that is the emphasis of this work. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| 3.pdf | 1397/08/05 | 11182555 | دانلود |