| Introduction: In thisclinicaltrial,theeffectof Elaeagnusangustifolia L. wholefruitandmedullapowdersonclinicalsymptomsoffemaleswith
knee osteoarthritis(OA)wasinvestigated.
Method: In thepresentrandomizeddoubleblindedplacebo-controlledstudy,ninetyfemaleswithmildtomoderatekneeosteoarthritiswere
randomly assignedtooneofthreegroups–medullapowder,wholefruitpowderorplacebofor8weeks.TheWOMACindexwasusedasaprimary
outcome andcrepitus,swelling,andjointinstabilitywereassessedassecondaryoutcomesbeforeandattheendofsupplementation.
Results: After 8weeksofsupplementation,comparedwiththebaseline,significantreductions inscoresofpain,stiffnessandphysicalfunction
were observedinthetwosupplementedgroups,however,thereductionofthesevalueswasnotstatisticallysignificantintheplacebogroup.There
were significantdifferencesbetweenthepatientsreceivingmedullapowderandtheplacebogroupinthecaseofchangesinpain(p < 0.001)and
physical function(p = 0.001)scores.However,nosignificantdifferenceswerefoundbetweenthewholefruitpowderandtheplacebogroupsor
between thetwosupplementedgroupsforchangesinanyscores(p > 0.01).Thenumberneededtotreat(99%CI)valuesforpatientswhoconsumed
medulla andwholefruitpowdersforatleast50%improvementinpain,were3(2–40)and6(−9 to2),respectively.
Discussion: Generally,medullapowderof E. Angustifolia L. hadpositiveeffects,especiallyinimprovingpainaswellasstiffnessandphysical
function infemaleswithkneeOA |