چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Modern societies tend to use medicinal plants for their basic health care needs. Elaeagnus angustifolia (E.A) is one of the medicinal herbs with antinociceptive, anti-inflammatory, antibacterial and antioxidant properties widely used in the treatment of patients with rheumatoid arthritis and osteoarthritis symptoms. In this work, for the first time, E.A extract was loaded on PCL-PEG-PCL nanofibers and studied their potential application in bone tissue engineering. Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscope (FE-SEM), contact angle and mechanical test were applied to evaluate the morphology and chemical properties of nanofibers. FE-SEM images showed that all samples had bead-free morphologies with average diameters ranging from 100-200 nm. The cell response to the E.A extract loaded PCL-PEG-PCL nanofibers was evaluated by means of human dental pulp stem cells (hDPSCs). hDPSCs showed improved adhesion and proliferation capacity on the E.A loaded nanofibers compare to pristine PCL-PEG-PCL nanofiber. Alizarin red S assay and alkaline phosphatase activity confirmed the nanofibrous scaffolds could induce the osteoblastic performance of hDPSCs (p<0.05). QRTPCR results confirmed that E.A loaded nanofibrous scaffolds significantly upregulated the gene expression correlated to osteogenic differentiation (p<0.05). The results suggested that E.A extract loaded with PCL-PEG-PCL nanofibers might have potential applications for bone tissue engineering |
| نویسنده | نفر چندم مقاله |
|---|---|
| سودابه داوران | دوم |
| مرضیه آقازاده | سوم |
| رویا صالحی قره ورن | پنجم |
| عفت علیزاده | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 77-Raisdasteh,Front. Chem. Sci. Eng,2019.pdf | 1398/02/28 | 4136034 | دانلود |
