| We performed a meta‐analysis to evaluate the efficacy of cumin supplementation on
plasma lipid concentration in adult population.
The search included PubMed, Scopus, ISI Web of Science, Google Scholar, and the
Cochrane library (up to January 2018) to identify randomized controlled trials (RCTs)
investigating the effects of cumin supplementation on serum lipid parameters. Mean
difference (MD) was pooled using a random‐effects model.
Meta‐analysis of data from six eligible RCTs with 376 participants showed a significant
reduction in plasma concentration of total cholesterol (MD [95% CI] −10.90
[−21.39, −0.42] mg/dl, p = 0.042) and low‐density lipoprotein cholesterol (MD [95%
CI] −6.94 [−11.53, −2.35] mg/dl, p = 0.003) after supplementation with cumin compared
with control treatment, and plasma concentration of high‐density lipoprotein
cholesterol (MD [95% CI] 3.35 [1.58, 5.12] mg/dl, p˂0.001) were found to be
increased. Although our analysis indicated that cumin supplementation cannot change
triglyceride (TG) concentration (MD [95% CI] −20.48 [−41.23, −0.26] mg/dl,
p = 0.053), but after stratified the RCTs based on the primary level of TG (hypertriglyceridemia
versus nonhypertriglyceridemia subjects), there was a significant
decrease in nonhypertriglyceridemia subset.
This systematic review and meta‐analysis suggested the efficacy of cumin supplementation
on lipid parameters. |